After posting my anti-Santana diatribe just hours ago, consider me sold now after reading this. That's not much to give up for one of the best pitchers in baseball.
I obviously like Jed Lowrie, but he's never even appeared in a major league game, as far as I can remember. Plus, the Red Sox infield is set for at least the next three years; he's expendable. Justin Masterson is great, but not MLB ready.
Go for it! You have my blessing.